Leal Therapeutics is seeking a highly driven Director of Preclinical Development to join its Translational Sciences team.

About Leal Therapeutics:

  • Biotechnology company developing novel, precision therapeutics for major diseases of the central nervous system (CNS) with critical unmet needs including ALS, Schizophrenia, and Alzheimer’s disease
  • Core operations in Worcester, MA and Philadelphia, PA
  • Fast-paced startup environment with broad exposure to multiple facets of biotechnology and drug development 
  • Emphasis on cross-functional collaboration within a collegial, learning-oriented environment
  • Continuous career development opportunities and support
  • Ability to have a large impact in a rapidly growing company

Key Responsibilities:

  • Develop and execute on preclinical plan to bring CNS therapeutics to IND
  • Provide scientific guidance and develop strategy for lead programs and pipeline
  • Lead and manage a scientific research team composed of Ph.D. and non-Ph.D. scientists
  • Manage external CROs to design and execute preclinical efficacy studies
  • Document and present results for study reports, conferences, and manuscripts
  • Author preclinical sections for regulatory submissions
  • Oversee internal lab operations and experiments
  • Train and mentor scientists and research associates
  • Contribute to cross-functional decision-making and execution
  • Contribute to strategy and development plans for translation from discovery to the clinic

Education, Experience, and Qualities Required:

  • Ph.D. in a relevant scientific discipline with 5+ years additional experience required

  • A minimum for 3 years in industry or preclinical drug development required

  • Experience in CNS disorders, molecular biology, and preclinical molecules required

  • Experience with oligonucleotides preferred

  • Strong organizational skillset with ability to manage multiple concurrent workstreams

  • Excellent verbal and written communication skills

  • Ability to work collaboratively in a fast-paced, dynamic environment

  • Passion for bringing new therapies to serve patients with unmet medical needs


Leal is an equal opportunity employer.  All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national orientation, veteran status, disability, or any other legally protected status.


If interested, please contact Human Resources (hr@lealtx.com) with a brief statement of interest and resume.